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. 2011 Dec 22;5(3):351–365. doi: 10.1242/dmm.002873

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms

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Fig. 4. — Early born neuronal populations are overproduced in Sall1^−/− mice. (A,B) Tuj1 (green) staining identified an increase in preplate size at E12.5 in Sall1-deficient animals (B) compared with controls (A). (C) Quantification of cortical cell number at E11.5 and E12.5. *, P<0.05; **, P<0.01. (D,E) CSPG (red) immunostaining of the subplate (bracketed region) and marginal zone identified an increase in these structures in Sall1^−/− mice (E) compared with controls (D) at E14.5. Note: CSPG is also expressed by the meninges at the pial surface. (F,G) Reelin (red) immunostaining identified an increase in Cajal-Retzius cells in Sall1^−/−mice (G) compared with controls (F) at E14.5. (A,B,D–G) Sections are counterstained with DAPI (blue). PP, preplate; PC, progenitor population; IZ, intermediate zone; SP, subplate; CP, cortical plate; MZ, marginal zone; P, pial surface. Scale bar: 100 μm (A,B); 200 μm (D,E); 400 μm (F,G).