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. 2011 Dec 12;5(3):389–396. doi: 10.1242/dmm.008631

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms

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Fig. 2. — neb embryos are morphologically abnormal and have disrupted birefringence. Live imaging of neb embryos and age-matched littermates (CTL) at 3 dpf (A) and 4 dpf (B). Compared with controls, neb zebrafish are smaller, have thin and bent tails, and have pericardial edema. The heart structure is not obviously abnormal (arrows and see supplementary material Movies 3, 4). (C) Live image analysis of 3 dpf embryos using polarized light to detect birefringence. Wild type (CTL) embryos have normal birefringence, whereas neb embryos have diminished and patchy birefringence. The pattern is variable between neb embryos. Depicted for comparison is an age-matched sapje (sap) embryo. sap zebrafish have a recessive mutation in dystrophin and abnormal birefringence.