Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jan 24;5(3):403–411. doi: 10.1242/dmm.008136

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms

PMC Copyright notice

Fig. 1. — Specific loss of PKBβ in aged mice results in the development of severe ovarian cysts with an increase in the thecal-interstitial cell population. (A) 91- to 120-week-old WT (i) and PKBβ KO (ii) mice with distended abdomens. (B) Cystic ovaries isolated from WT (i) and PKBα KO (iii) mice show no atresia or small ovarian cyst formation, whereas PKBβ KO mice show severe ovarian cyst formation. (C) Increased stromal accumulation in 91-week-old (early; i, iii) and 120-week-old (late; ii, iv) aged PKBβ KO mice, shown by H&E staining (i, ii). This accumulation reflects increased thecal-interstitial hyperplasia, as indicated by positive vimentin immunohistochemical staining (iii, iv). 40× magnification.