Table 4.

Overrepresented and conserved transcription factor binding sites of inflammatory genes selectively induced by IL-1β in SMCs

Transcription Factor Binding Site	Number of Hits in Submitted Regions	Total Number of Hits on Genome	P Value	Annotated Genes With Hits in Promoter Region
NFKAPPAB65	23	2,232	3.5 × 10−10	Ccl20, Ccl5, Cd74, Cxcl2, Cxcl6, Il1r1, Il6, Jak2, Map2k3, Nfkbiz, Pdgfra, Ptges, Timp1, Vcam1, Vcan
NFKAPPAB50	16	2,308	2.3 × 10−5	Ccl20, Cd74, Cxcl2, Cxcl6, Il1r1, Map2k3, Nfkbiz, Pdgfra, Tgfb1, Vcam1, Vcan
NFKAPPAB	68	23,956	2.7 × 10−3	Arg1, Bmp6, Ccl20, Ccl5, Cd74, Clu, Cxcl2, Cxcl6, Elk3, Gch1, Hif1A, Il1r1, Il6, Jak2, Lyn, Map2k3, Nfkbiz, Nos2, Pdgfra, Pkm2, Rbpj, Selp, Tgfb1, Timp1, Vcam1, Vcan
ISRE	5	485	3.0 × 10−3	Bmp6, Il6, Rbpj, Selp