Fig. 5.
Measurements of contractile function in WT, eNOS−/−, and nNOS−/− mice. A: at baseline, peak Ecc (representing maximal contraction) was similar in all mice. WT and eNOS−/− mice, but not nNOS−/− mice, demonstrated a strong inotropic response to Dob as measured by Ecc (B) and systolic strain rate (dEcc/dt; C), which was reversed in response to Dob + CCh. D: only WT mice demonstrated a strong lusitropic response to Dob, which was reduced with Dob + CCh. *P < 0.05 vs. WT.