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Effect of 5, 10, or 30 min treatment with M22 (10 or 100 ng/ml; filled symbols) alone or in combination with 1H7 (5 μg/ml) on pAkt protein levels in GO orbital fibroblast cultures (n = 6). Levels of pAkt are expressed as mean ± sem fold change relative to parallel control cultures treated with M22 alone. *, P < 0.05; **, P < 0.001.
