Table 4.
Histomorphometry by renal function
| GFR <60 (n = 5) | GFR ≥60 (n = 25) | P value | |
|---|---|---|---|
| Structural indices | |||
| Cortical width (μm) | 695 ± 184 | 626 ± 209 | 0.51 |
| Cancellous bone volume (%; BV/TV) | 22.1 ± 6.2 | 23.2 ± 7.0 | 0.75 |
| Trabecular number (1/mm) | 1.82 ± 0.23 | 1.93 ± 0.42 | 0.61 |
| Trabecular separation (μm) | 435 ± 92 | 424 ± 134 | 0.88 |
| Trabecular width (μm) | 121 ± 35 | 119 ± 25 | 0.89 |
| Remodeling indices | |||
| Osteoid surface (%) | 25.2 ± 12.7 | 29.3 ± 12.6 | 0.52 |
| Osteoid width (no. lamellae) | 13.3 ± 1.3 | 13.5 ± 3.1 | 0.88 |
| Mineralization lag time (d) | 34 ± 14 | 50 ± 34 | 0.59 |
| Mineralizing surface (%) | 19.0 ± 11.3 | 19.3 ± 10.3 | 0.95 |
| Mineral apposition rate (μm/d) | 0.65 ± 0.09 | 0.63 ± 0.12 | 0.69 |
| Bone formation rate (μm3/μm2 · d) | 0.13 ± 0.09 | 0.11 ± 0.06 | 0.63 |
| Eroded surface (%) | 12.0 ± 4.2 | 8.3 ± 2.7 | 0.02a |
| Activation frequency (cycles/yr) | 0.62 ± 0.15 | 1.07 ± 0.62 | 0.25 |
Values represent mean ± sd. BV/TV, Bone volume/tissue volume.
a
Statistically significant when controlling for multiple comparisons.