Table 3.
Cardiovascular risk markers
| Measure | Active CD | Remission | Pa |
|---|---|---|---|
| HOMA-IR | 3.1 ± 1.9 | 1.3 ± 0.7 | 0.0004 |
| Leptin (ng/ml) | 41.3 ± 20.3 | 23.0 ± 17.8 | 0.00002 |
| CRP (mg/liter)b | 5.2 (1.1–12.5) | 1.8 (1.3–15.2) | 0.69 |
| HMWApN (μg/ml)b | 6.0 (2.6–8.4) | 6.1 (2.9–6.5) | 0.43 |
| TC (mg/dl) | 202.5 ± 36.1 | 186.4 ± 32.5 | 0.03 |
| TG (mg/dl) | 121.2 ± 55.2 | 109.4 ± 65.3 | 0.55 |
| LDL (mg.dl) | 117.2 ± 31.6 | 107.0 ± 25.1 | 0.08 |
| HDL (mg/dl) | 61.2 ± 16.4 | 57.4 ± 13.3 | 0.20 |
| TC/HDL | 3.5 ± 1.2 | 3.4 ± 0.8 | 0.53 |
| LDL/HDL | 2.1 ± 0.9 | 2.0 ± 0.6 | 0.55 |
Data are presented as mean ± sd or median (interquartile range). P values for CRP and HMWApN are from Ln (natural logarithm) values. HOMA-IR = [fasting serum insulin (microunits per milliliter) × fasting plasma glucose (millimoles per liter)/22.5]. CRP <1.0 mg/liter indicates low cardiovascular risk, 1.0–3.0 average risk, and >3.0 high risk (10). HOMA-IR ≥2.77 indicates insulin resistance (25). Two patients (7 and 12) were taking lipid-lowering medications at both visits.
a
From paired t test.
b
For these measures, n = 13. CRP was excluded in patient 6 due to cough and congestion at postoperative visit, and patient 13 had postoperative HMWApN values below the range of detection.