Table 1.
Effects of mifepristone treatment on body weight and serum glucose, hormones, and lipids levels
| Mifepristone (n = 14) |
Placebo (n = 10) |
|||
|---|---|---|---|---|
| Day 0 | Day 43 | Day 0 | Day 43 | |
| Weight (kg) | 70.0 (65, 81) | 69.7 (65, 82) | 62.5 (55, 71) | 63.6 (56, 71) |
| BMI (kg/m2) | 25.6 (23, 28) | 25.8 (24, 29) | 24.3 (21, 26) | 24.8 (21, 26) |
| ACTH (pg/ml) | 14.5 (11, 24) | 99 (70, 171)a,b | 13 (10, 18) | 13 (11, 17) |
| Cortisol (μg/dl) | 14.8 (13, 16) | 41 (39, 53)a,b | 14.6 (12, 20) | 12.1 (10, 14) |
| Estradiol (pg/ml) | 8.0 (0, 21) | 26.5 (10, 44)a,b | 8.0 (0, 13) | 8.5 (0, 24) |
| Total testosterone (ng/dl) | 15.0 (11, 21) | 51.5 (45, 71)a,b | 12.5 (7, 14) | 13.0 (7, 16) |
| Glucose (mg/dl) | 92.0 (85, 99) | 88.5 (85, 92) | 92.0 (85, 99) | 91.0 (86, 97) |
| Insulin (μU/ml) | 12.0 (8, 21) | 10.0 (7, 11)a | 11.0 (10, 14) | 10.5 (8, 18) |
| HOMA-IR | 2.5 (1.9, 5.2) | 2.2 (1.4, 2.4)a | 2.4 (2.2, 2.9) | 2.2 (1.7, 4.4) |
| Total cholesterol (mg/dl) | 226 (204, 238) | 180 (149, 222)a,b | 231 (206, 238) | 234 (213, 251) |
| Triglyceride (mg/dl) | 96 (78, 121) | 111 (82, 146) | 104 (72, 188) | 84 (69, 170) |
| LDL-C (mg/dl) | 119 (83, 129) | 100 (83, 129)b | 123 (112, 147) | 127 (111, 165) |
| HDL-C (mg/dl) | 70 (49, 59) | 53 (49, 59)a,b | 76 (46, 87) | 75 (52, 91) |
All data are presented as median (25th, 75th percentiles).
a
P < 0.05 vs. baseline (Friedman two-way ANOVA for ranks).
b
P < 0.05 for differences vs. placebo in change from baseline (Wilcoxon rank sum test).