Figure 5.
VEGF-C promotes DC maturation. (A, B) Recipient (Iad) and donor (Iab) APCs from ipsilateral draining lymph nodes express significantly lower levels of MHC class II after anti-VEGF-C blockade (day 1 to day 3 after corneal transplantation. Anti-VEGF-C administration significantly reduced MHC class II expression by both donor and recipient after transplantation. (C) Bone marrow–derived DCs were matured either by LPS alone or LPS in the presence of 10 ng/mL VEGF-C for 24 hours. LPS-induced DC maturation was associated with overexpression of MHC class II, which was augmented in the presence of VEGF-C. Data are representative of three different experiments.