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Schematic diagram summarizing the mechanisms via which anti-VEGF-C therapy suppress alloimmunity. VEGF-C binding to VEGFR-2 and VEGFR-3 induces hemangiogenesis and lymphangiogenesis, respectively. VEGF-C also promotes maturation and migration of APC to lymphoid tissues. iAPCs, immature antigen-presenting cells; mAPCs, mature antigen-presenting cells.
