Table 3.
MAFs of SNPs in Progressors and Nonprogressors at Each Transition
SNP | Gene | Transition Minor Allele | 1 → 2 |
2 → 3 |
3 → 4 |
3 → 5 |
||||
---|---|---|---|---|---|---|---|---|---|---|
Non* | Pro* | Non* | Pro* | Non* | Pro* | Non* | Pro* | |||
Subjects, n | 219 | 494 | 814 | 376 | 949 | 280 | 949 | 298 | ||
rs1061170 | CFH | C | 0.37 | 0.39 | 0.36 | 0.43 | 0.44 | 0.62 | 0.44 | 0.62 |
rs10490924 | ARMS2/HTRA1 | T | 0.17 | 0.21 | 0.20 | 0.28 | 0.28 | 0.41 | 0.28 | 0.41 |
rs9332739 | C2 | C | 0.06 | 0.05 | 0.05 | 0.04 | 0.04 | 0.02 | 0.04 | 0.02 |
rs641153 | CFB | T | 0.11 | 0.09 | 0.09 | 0.07 | 0.08 | 0.05 | 0.08 | 0.04 |
rs2230199 | C3 | G | 0.19 | 0.21 | 0.20 | 0.25 | 0.24 | 0.32 | 0.24 | 0.31 |
rs10033900 | CFI | T | 0.45 | 0.51 | 0.49 | 0.49 | 0.49 | 0.57 | 0.49 | 0.49 |
rs10468017 | LIPC | T | 0.34 | 0.29 | 0.28 | 0.28 | 0.29 | 0.24 | 0.29 | 0.26 |
rs9621532 | TIMP3 | C | 0.06 | 0.05 | 0.05 | 0.06 | 0.06 | 0.04 | 0.06 | 0.04 |
rs3764261 | CETP | A | 0.31 | 0.34 | 0.33 | 0.35 | 0.34 | 0.33 | 0.34 | 0.39 |
rs1883025 | ABCA1 | T | 0.32 | 0.24 | 0.26 | 0.21 | 0.24 | 0.24 | 0.24 | 0.25 |
rs13095226 | COL8A1 | C | 0.09 | 0.11 | 0.11 | 0.07 | 0.08 | 0.14 | 0.08 | 0.12 |
APOE† | APOE | E4 | 0.14 | 0.13 | 0.12 | 0.10 | 0.12 | 0.09 | 0.12 | 0.10 |
Nonprogressors (Non) groups and progressors (Pro) for each transition in the five-state Markov model.
APOE haplotypes were defined by alleles in rs7412 and rs429358.