Table 1.
iSyTE Rank of Genes Associated with Human Isolated Congenital Cataract
| Gene | Chr | Interval Size (Mb) | No. Genes | iSyTE Rank | Reference |
|---|---|---|---|---|---|
| BFSP1 | 20 | 5.43 | 22 | 1 | 16 |
| BFSP2 | 3 | 17.88 | 106 | 1 | 17 |
| CHMP4B | 20 | 3.03 | 43 | 34 | 18 |
| CRYAA1 | 21 | 2.79 | 37 | 1 | 19 |
| CRYAB | 11 | 21.08 | 99 | 1 | 20 |
| CRYBA1 | 17 | 15.20 | 129 | 1 | 21 |
| CRYBA4 | 22 | 0.40 | 6 | 1 | 22 |
| CRYBB1 | 22 | 2.54 | 21 | 2 | 23 |
| CRYBB2 | 22 | 1.47 | 5 | 2 | 24 |
| CRYBB3 | 22 | 3.76 | 31 | 1 | 25 |
| CRYGC | 2 | 32.97 | 129 | 1 | 26 |
| CRYGD | 2 | 32.97 | 129 | 2 | 26 |
| CRYGS | 3 | 2.76 | 31 | 1 | 27 |
| EPHA2 | 1 | 5.75 | 67 | 1 | 28 |
| FYCO1 | 3 | 12.21 | 191 | 21 | 29 |
| GCNT2 | 6 | 5.26 | 21 | 7 | 30 |
| GJA3 | 13 | 8.69 | 50 | 1 | 31 |
| GJA8 | 1 | 46.04 | 299 | 1 | 32 |
| HSF4 | 16 | 11.41 | 102 | 2 | 33 |
| *LIM2 | 19 | 6.71 | 103 | 1 | 34 |
| MAF | 16 | 5.01 | 18 | 1 | 35 |
| MIP | 12 | 24.00 | 144 | 1 | 36 |
| PXDN | 2 | 6.68 | 18 | 1 | 37 |
| TDRD7 | 9 | 21.08 | 108 | 1 | 38 |
iSyTE rank is obtained by comparing the lens enrichment of all the genes within a given interval at each of E10.5, E11.5, and E12.5. The overall iSyTE rank is the minimum of the ranking of these three stages.
*
Mutations in LIM2 are associated with both congenital and pre-senile cataract.