Table 3.
iSyTE Predicted Candidate Genes in Mapped Intervals for Human Cataract
| Chromosome Location (reference) | No. Genes (minRank ≤500)*/No. Genes in Interval | Genes with minRank ≤500 (in order) | Reference |
|---|---|---|---|
| 1pter-p36 | 3/36 | MXRA8, FAM132A, Clorf159 | 44 |
| 1p35.3-p36.32 | 18/266 | LIN28A, PTPRU, ALPL, MAN1C1, AGTRAP, DNAJC16, EPHA2, ESPN, C1QB, CD52, SLC25A33, C1QA, MECR, SPSB1, KLHL21, NIPAL3, FAM54B, CLCN6 | 41 |
| 1p34.3-p32.2 | 11/199 | DMRTA2, FOXE3, RSPO1, SLC2A1, PTPRF, YBX1, HYI, PRKAA2, AKIRIN1, INPP5B, Clorf109 | 45 |
| 1q25-q31 | 0/1 | — | 46 |
| 2p24-pter | 1/39 | PXDN | 47 |
| 2p12 | 2/11 | TACR1, FAM176A | 48 |
| 2q33 | 0/26 | — | 49 |
| 3q26.1–3q27.2 | 8/84 | CRYGS, GPR160, PLD1, PRKCI, ETV5, TTC14, FAM131A, MAP6D1 | 50 |
| 7q21.11-q31.1 | 11/179 | NRCAM, STEAP1, PON2, C7orf51, SEMA3A, LAMB1, CDK6, C7orf23, SLC25A13, STEAP2, SLC25A40 | 51 |
| 8p23.2-p21.3 | 5/78 | SLC7A2, MSRA, RHOBTB2, MTMR7, FAM86B2 | 52 |
| 15q22.32-q24.2 | 3/45 | TMED3, PEAK1, FAH | 53 |
| 17p13 | 1/90 | ENO3 | 54 |
| 17p24 | 0/15 | — | 55 |
| 19q13 | 8/201 | SIPA1L3, PRX, EML2, SPINT2, PVRL2, PLD3, SLC1A5, TRAPPC6A | 40 |
| 19q13-qter | 1/88 | LENG8 | 56 |
| 20p11.23-p12.1 | 1/29 | BFSP1 | 57 |
| Xq24 | 3/35 | NDUFA1, UPF3B, AKAP14 | 58 |
*
minRank is the smallest rank value of that gene across the three embryonic stages with respect to all the genes in the lens microarray. For example, if a gene is ranked 12, 401, and 214 at E10.5, E11.5, and E12.5, respectively, the minRank is 12. A gene with a minRank below 500 will have a bright red color in the iSyTE track in UCSC Genome Browser.