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. 2012 Mar 26;53(3):1663–1669. doi: 10.1167/iovs.11-8871

Figure 1.

Figure 1.

Variation of ONL thickness in Tulp1-deficient mice is variable in a segregating genetic background. Wildtype (WT) F2 progeny from a B6-Tulp1tm1Pjn/tm1Pjn × AKR/J intercross showed normal thickness and arrangement of retinal layers (A). GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; OPL, outer plexiform layer; ONL, outer nuclear layer; IS, inner segment; OS, outer segment; RPE, retinal pigment epithelium. F2 Tulp1tm1Pjn/tm1Pjn progeny showed attenuated ONL, IS, and OS layers, with considerable variability in the ONL appearance (B–F). Arrows: ONL layer in Tulp1-deficient progeny. Bar: 50 μm.