Figure 4.

Mtap1a modifies photoreceptor cell loss in Tub^tub/tub retinas (A). Previous QTL studies suggested a retinal-protective locus on chromosome 2, similar to findings with Tulp1 (reprinted with permission from the International Society for Eye Research/Elsevier Publishers³⁴). Retinal micrographs reveal fewer ONL nuclei in Tub^tub/tub mice lacking a transgenic copy of the 129P2/OlaHsd Mtap1a^moth1-r gene (tg−, B) than in those containing the transgene (tg+, C). Retinal layers are labeled as in Figure 1A. Bar: 50 μm. ONL nuclei counts (mean ± SE) indicate a significantly higher number of photoreceptor cells in tg+ mice (D). Asterisk: P < 0.04.