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AFD sterically prevents FD from binding to C3bB proconvertase. A, residues in FD (white ribbon representation, from the FD-AFD complex) in contact with AFD (orange sticks). B, residues in FD (yellow ribbon representation, from the C3bBD complex) in contact with FB (pink sticks). C, modeling of a major steric clash between FB (pink) and the AFD HC (orange) and LC (yellow). Dark blue indicates the C3b β-chain, and light blue indicates the C3b α-chain.
