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. 2012 Feb 23;287(16):12828–12834. doi: 10.1074/jbc.M111.336750

FIGURE 2.

FIGURE 2.

rs9444584 allele frequency varies greatly in different human populations and changes the predicted affinity of AP1 transcription factor. A, pairwise alignment of the human and chicken ECR1 sequences showing predicted transcription factor binding sites and allelic variants of rs944458. AR, androgen receptor; C/EBP, CCAAT enhancer-binding protein; TFII-A, transcription factor II A. B, table from the National Center for Biotechnology Information (NCBI) SNP web site showing population diversity of rs944458 in European, Asian, and sub-Saharan African populations. C, table generated by the RegSNP algorithm showing predicted relative binding affinities of each allele of rs944458 to the AP1 transcription factor. Matrix score and core score values represent the probability that AP1 will bind to each allelic binding site. D, diagrammatic representation of each of the plasmid constructs used in the current study (not to scale). Bent arrows represent the transcriptional start site of the luciferase gene. ss#, assigned submitter SNP ID, Chrm. Sample. Cnt, chromosome sample count, IC, individual Genotype, and GF, genotype frequency.