TABLE 1.

Relative permeability of ASIC1a mutants toward alkali metals

Whole-cell currents were elicited by a change in extracellular pH from 8.0 to 5.0. The peak current evoked by extracellular acidification with a defined alkali metal as the main permeable cation was normalized to the peak current evoked by extracellular acidification with Na⁺ as the main permeable cation. Statistically significant differences with the control (C70L) are indicated as *, p < 0.05, **, p < 0.01, and ***, p < 0.001 (n = 7–41) (Kruskal-Wallis test followed by Dunn's multiple comparisons test).

	Li+/Na+	Na+/Na+	K+/Na+	Rb+/Na+	Cs+/Na+
C70L	0.85 ± 0.03	1.00 ± 0.04	0.33 ± 0.02	0.06 ± 0.01	0.02 ± 0.01
M437C	0.75 ± 0.05	1.00 ± 0.02	0.49 ± 0.02*	0.25 ± 0.03	0.20 ± 0.03
G438A	1.18 ± 0.03*	1.00 ± 0.02	1.29 ± 0.09***	0.94 ± 0.03***	1.29 ± 0.07***
G438C	1.40 ± 0.06***	1.00 ± 0.01	0.96 ± 0.03***	1.23 ± 0.05***	1.38 ± 0.05***
A443C	0.60 ± 0.04	1.00 ± 0.06	0.59 ± 0.04**	0.25 ± 0.03	0.25 ± 0.02
L446C	1.05 ± 0.03	1.00 ± 0.02	1.05 ± 0.02***	1.04 ± 0.04***	1.05 ± 0.04***