TABLE 2.
Inhibition constants and mechanisms of inhibition for JNK1β1
Results are the average of at least three separate experiments done in quadruplicate ± S.E.
| Inhibitor | Variable substrate | Type of inhibition | Ki |
|---|---|---|---|
| μm | |||
| AMP-PCP | ATP | Competitive | 29.2 ± 3.1 |
| B-F-ATF2 | Noncompetitive | 115.6 ± 66.8 | |
| JIP1 pep | ATP | Noncompetitive | 0.492 ± 0.196 |
| B-F-ATF2 | Competitive | 0.078 ± 0.015 | |
| AMP-PCP | ATP | Competitive | 91.5 ± 46.8 |
| H-N-cJun | Noncompetitive | 487.8 ± 129.1 | |
| JIP1 pep | ATP | Noncompetitive | 0.318 ± 0.074 |
| H-N-cJun | Competitive | 0.173 ± 0.039 |