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. 2012 Feb 29;287(16):12750–12758. doi: 10.1074/jbc.M111.337907

FIGURE 5.

FIGURE 5.

Sir2 and FOXO ameliorate DA neuronal degeneration in PINK1 null mutants. A, images of the DA neurons within the DL1 cluster of adult brain from wild type control (TH), PINK1 mutants (B9, TH), Sir2-expressing PINK1 null mutants (B9, TH>Sir2), Sir2-expressing PINK1 null mutants with a heterozygous FOXO mutation (B9, TH>Sir2, FOXO−/+), SOD2-expressing PINK1 null mutants (B9, TH>SOD2), and Thor-expressing PINK1 null mutants (B9, TH>Thor). DA neurons were stained with anti-TH antibody (green) B, graph showing the average number of DA neurons in DL1 clusters (n = 40). Significance was determined by one-way ANOVA with Bonferroni's correction (***, p < 0.001). Error bars indicate mean ± S.D. Scale bars: white, 20 μm.