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. 2012 Feb 29;287(16):12750–12758. doi: 10.1074/jbc.M111.337907

FIGURE 6.

FIGURE 6.

PINK1, Sir2, and FOXO act in same pathway in preventing DA neuron loss. A, images of the DA neurons within the DL1 cluster of adult brain from wild type control (WT), PINK1 null mutants (B9), Sir2 mutants (Sir2−), PINK1 and Sir2 double mutants (B9, Sir2−), FOXO mutants (FOXO−), and PINK1 and FOXO double mutants (B9, FOXO−). DA neurons were stained with anti-TH antibody (green). B, graph showing the average number of DA neurons in DL1 clusters (n = 40). Significance was determined by one-way ANOVA with Bonferroni's correction (***, p < 0.001; NS, not significant). Error bars indicate mean ± S.D. Scale bar: white, 20 μm.