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. 2012 Feb 23;287(16):12858–12866. doi: 10.1074/jbc.M111.255836

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Analysis of PrP-AA in the culture system. The PrP-AA prevented PrP_106–126(A117V) induced neurotoxicity in a neuron-glia co-culture system. Purified PrP-AA significantly blocked PrP_106–126(A117V) fibril-induced neuronal death in the co-cultured system. CGN-glia were treated with 50 μm PrP_106–126(A117V) fibril only and PrP_106–126(A117V) fibril that had been preincubated with 0.07 μm PrP-AA for 24 h. Cell viability was determined by staining neurons with fluorescein diacetate/propidium iodide. Values are expressed as percentages (%) of control (untreated). The data represent the mean ± S.D. (bars) values of triplicate determinations from a single but representative experiment, which has been repeated three times with similar results (**, p < 0.01, by one-way ANOVA). PrP, PrP_106–126(A117V) peptides; E, PrP-AA; PT, pass-through IgG depleted of PrP-AA.