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Generation of Abcb6−/− mice. A, construct used. B, PCR analysis of genomic DNA from wild-type, Abcb6+/−, and Abcb6−/− mice. The wild-type allele amplifies a 0.6-kb fragment and the null allele a 1.2-kb fragment. C, Western blot (upper panel) and quantitative graph (lower panel) of Abcb6 in mitochondria isolated from various tissues of adult Abcb6−/− mice. A separate gel was used for bone marrow lysates. VDAC, voltage-dependent anion channel.
