FIGURE 3.

Gene expression screening of Abcb6^−/− mice. A, during in vitro erythroid differentiation, Abcb6 is up-regulated simultaneously with heme biosynthesis genes. B, transcripts were compared in erythroblasts from 1-month-old female wild-type and Abcb6^−/− mice. Genes whose expression changed by a factor of 2 or more included more than 110 mitochondrial genes and 66 known erythroid-associated genes (candidate genes). C, more than 314 arrays were searched to identify genes consistently coexpressed with the candidate genes.