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. 2012 Jan 31;287(16):12679–12690. doi: 10.1074/jbc.M111.336180

FIGURE 4.

FIGURE 4.

Increased mortality and impaired stress erythropoiesis in Abcb6−/− mice. A, EKLF and FECH protein expression is greater in Abcb6−/− than Abcb6+/+ hematopoietic cells. B, mortality on days 3–7 of Phz treatment. C–F, mean (±S.E.) hematologic parameters of 1-month-old female mice injected with Phz on days 0, 1, and 3 (total dose, 50 mg/kg). C, hematocrit (n = 11–30 Abcb6+/+, 13–46 Abcb6−/− mice). D, corrected reticulocyte count (n = 9–25 Abcb6+/+, 12–37 Abcb6−/− mice). E, red cell distribution width (RDW) (n = 10–26 Abcb6+/+, 13–44 Abcb6−/− mice). F, hemoglobin (n = 10–26 Abcb6+/+, 13–42 Abcb6−/− mice). G, mean corpuscular volume (MCV) (n = 8–27 Abcb6+/+, 9–38 Abcb6−/− mice). *, p = 0.02–0.03; **, p = 0.01–0.02; ***, p = 0.003–0.009; ****, p = <0.002.