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. 2012 Jan 31;287(16):12679–12690. doi: 10.1074/jbc.M111.336180

FIGURE 5.

FIGURE 5.

Erythroblast response to stress erythropoiesis is altered in Abcb6−/− mice. A, serum erythropoietin assayed by ELISA in Abcb6+/+ mice that were untreated (n = 7), at day 8 of Phz treatment (n = 5), or at day 10 of Phz treatment (n = 5) and in Abcb6−/− mice that were untreated (n = 7), at day 8 of Phz treatment (n = 4), or at day 10 of Phz treatment (n = 8). B, duration of erythrocyte survival in 2–4 Abcb6+/+ and 6–7 Abcb6−/− Phz-treated mice. Day 0 of N-hydroxysuccinimide-biotin labeling = day 6 or 7 of the Phz regimen. C, apoptotic spleen and bone marrow Ter119-positive cells on day 8 of Phz treatment in 9 Abcb6+/+ and 10 Abcb6−/− mice. D, percentage of splenic reticulocytes on days 8 and 10 in 3–4 Abcb6+/+ and 5–6 Abcb6−/− mice. E, erythroid CFU in spleens of Abcb6+/+ mice that were untreated (n = 5), at day 8 of Phz treatment (n = 11), at day 10 of Phz treatment (n = 9), and Abcb6−/− mice that were untreated (n = 6), at day 8 of Phz treatment (n = 14), or at day 10 of Phz treatment (n = 7) on days 8 and 10. Values are means (±S.E.).