TABLE 3.

The final 72 candidates identified by gene expression screening

Gene	Description	Integrated probability	EKLF targeta	Unique heme biosynthetic genesb	Mitochondrial
CPOX	Coproporphyrinogen oxidase	0.999	X	X	X
FECH	Ferrochelatase	0.999	X	X	X
HMBS	Hydroxymethylbilane synthase	0.999	X	X	X
EKLF	Krüppel-like factor 1 (erythroid)	0.999	X
UROD	Uroporphyrinogen decarboxylase	0.999	X	X
PPOX	Protoporphyrinogen oxidase	0.999			X
UROS	Uroporphyrinogen III synthase	0.999		X
NFE2	Nuclear factor, erythroid-derived 2	0.998	X
EG623818	Predicted gene, EG623818 HMBS	0.998
ALAD	Aminolevulinate dehydratase	0.998
ALAS2	Aminolevulinate, δ-synthase 2	0.997			X
ICAM4	Intercellular adhesion molecule 4	0.996	X
EIF2AK1	Eukaryotic translation initiation factor 2α kinase 1	0.993
GLRX5	Glutaredoxin 5 homolog (Saccharomyces cerevisiae)	0.992		X	X
EG627557	Predicted gene, EG627557	0.989		X	X
BLVRB	Biliverdin reductase B	0.988	X
BZRPL1	Benzodiazepine receptor, peripheral-like 1	0.986
TXNRD2	Thioredoxin reductase 2	0.984		X	X
PCX	Pyruvate carboxylase	0.981	X		X
EPB4.1	Erythrocyte protein band 4.1	0.981
TFRC	Transferrin receptor	0.977	X
HSCB	HscB iron-sulfur cluster co-chaperone homolog (Escherichia coli)	0.977			X
MTHFD2	Methylenetetrahydrofolate dehydrogenase 2	0.976			X
CD24A	CD24a antigen	0.975	X
MGST3	Microsomal glutathione S-transferase 3	0.971	X
SLC25A38	Solute carrier family 25, member 38	0.968			X
TSPO	Translocator protein	0.96	X		X
BNIP3L	BCL2/adenovirus E1B interacting protein 3-like	0.96			X
ATPIF1	ATPase inhibitory factor 1	0.957		X	X
ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	0.951
HAGH	Hydroxyacyl glutathione hydrolase	0.95		X	X
MCART1	Mitochondrial carrier triple repeat 1	0.945		X	X
HBB-BH1	Hemoglobin Z, β-like embryonic chain	0.94	X
GLUL	Glutamate-ammonia ligase (glutamine synthetase)	0.92			X
NDUFB9	NADH dehydrogenase (ubiquinone) 1 b 9	0.918			X
MGLL	Monoglyceride lipase	0.916	X
PRDX2	Peroxiredoxin 2	0.909	X	X	X
EPB4.9	Erythrocyte protein band 4.9	0.908	X
HK1	Hexokinase 1	0.901		X	X
MYD116	Myeloid differentiation primary response gene 116	0.877	X
SLC48A1	Solute carrier family 48 (Hrg1)	0.875
HAX1	HCLS1 associated X-1	0.874			X
BPGM	2,3-Bisphosphoglycerate mutase	0.857
GMPR	Guanosine monophosphate reductase	0.841	X
RFESD	Rieske (Fe-S) domain containing	0.826
ISCA1	Iron-sulfur cluster assembly 1 homolog (S. cerevisiae)	0.824		X	X
NT5C3	5′-Nucleotidase, cytosolic III	0.808		X	X
COX7A2	Cytochrome c oxidase, subunit VIIa 2	0.754			X
SLC25A37	Solute carrier family 25, member 37	0.75		X	X
FTH1	Ferritin heavy chain 1	0.747
HBB-Y	Hemoglobin Y, β-like embryonic chain	0.736
SOD2	Superoxide dismutase 2, mitochondrial	0.733			X
COX5B	Cytochrome c oxidase, subunit Vb	0.731			X
ATP5L	ATP synthase mitochondrial F0 complex	0.709			X
FARS2	Phenylalanine-tRNA synthetase 2 (mitochondrial)	0.653			X
MRS2	Magnesium homeostasis factor homolog (S. cerevisiae)	0.648			X
GPX4	Glutathione peroxidase 4	0.629	X
SLC25A39	Solute carrier family 25, member 39	0.591		X	X
ATP5K	ATP synthase, F1F0 complex, subunit e	0.543			X
2010107E04RIK	RIKEN cDNA 2010107E04 gene	0.53			X
COX6A1	Cytochrome c oxidase, subunit VI a, polypeptide 1	0.516			X
AIP	Aryl hydrocarbon receptor-interacting protein	0.503			X
LARS2	Leucyl-tRNA synthetase, mitochondrial	0.486			X
BCL2L1	BCL2-like 1	0.443			X
EBF3	Early B-cell factor 3	0.428
COX6C	Cytochrome c oxidase, subunit VIc	0.425			X
UQCRH	Ubiquinol-cytochrome c reductase hinge protein	0.419			X
ACTB	Actin, β	0.415
NDN	Necdin (Ndn), mRNA	0.41
THSD7B	Thrombospondin, type I, domain containing 7B	0.398	X
ISCU	IscU iron-sulfur cluster scaffold homolog (E. coli)	0.364			X
FIS1	Fission 1 homolog (yeast)	0.272			X

^a Data are from Drissen et al. (24).

^b Data are from Nilsson et al. (11).