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KN-62 (30 μm) and EGF (100 ng/ml) both acutely stimulate NHE3 activity in Caco-2BBe/HA-NHE3 cells in a nonadditive manner. Caco-2BBe cells expressing HA-NHE3 were exposed to KN-62 and EGF for 30 min, and the apical NHE3 activity was determined (initial rates). Both stimulated NHE3 activity similarly with the effects not being additive. Results are from 3 to 4 experiments, with p values representing comparison to untreated controls (Ctrl) (paired t tests).
