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. Author manuscript; available in PMC: 2012 Oct 26.
Published in final edited form as: Nature. 2012 Apr 25;484(7395):524–528. doi: 10.1038/nature11042

Figure 1. Profiling of SPM in E. coli infections.

Figure 1

Mice were inoculated with E. coli at (a) 105 or (b) 107 CFU by intraperitoneal injection, and peritoneal leukocytes enumerated. Results are expressed as mean±s.e.m., n=4-6. See Methods for calculation of resolution indices. *p<0.05, **p<0.01, vs. 24h; #p<0.05, ##p<0.01, ###p<0.001, vs. 48h. (c) Time course of SPM and related pathway markers. Results are expressed as mean±s.e.m. of n=5 separate time courses. *p<0.05, **p<0.01, self-resolving (105 CFU) vs. higher titer (107 CFU) E. coli exudates. (d) Representative MRM chromatograph of eicosanoid, resolvin and protectin pathway products from naive germ-free mice. Each LM was identified based on published LC-MS-MS30 (see Table S1). (e) SPM and pathway markers in colons of germ-free and conventional mice; representative of 3 mice. (f) Representative MS-MS of RvD1 (from germ-free mice) and RvD5 (from E. coli-infected mice); a=[M-H] (parent ion).