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. Author manuscript; available in PMC: 2012 Oct 26.
Published in final edited form as: Nature. 2012 Apr 25;484(7395):524–528. doi: 10.1038/nature11042

Figure 2. RvD1 and RvD5 protect mice during infection: enhancing bacterial killing and preventing hypothermia.

Figure 2

Mice were inoculated with E. coli (107 CFU) together with RvD1 or RvD5 methyl ester (100 ng), and peritoneal exudates collected 24h later. (a) Intracellular E. coli levels. MFI denotes mean fluorescence intensity. Results are expressed as mean of n=3-5. (bottom panel) Representative histograms. (b) Bacterial titers. Results are expressed as mean of n=4-5. (c) Changes in body temperatures expressed as mean of Δ°C (24h-0h) n=4-10. *p<0.05, **p<0.01, vs. E. coli alone; ##p<0.01, vs. naïve mice. (d) % survival of E. coli inoculated mice (2.5×107 CFU) alone or with RvD1 (100 ng/mouse). *p<0.05 log-rank (Mantel-Cox) test, n=12 each group.