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. Author manuscript; available in PMC: 2012 Oct 26.
Published in final edited form as: Nature. 2012 Apr 25;484(7395):524–528. doi: 10.1038/nature11042

Figure 3. SPM enhance human macrophage phagocytosis of E. coli.

Figure 3

(a-c) MΦ phagocytosis of fluorescent E. coli in the presence of PD1, RvD1 or RvD5. Results are percent increase above vehicle and expressed as mean±s.e.m., d=3-4, n=3 (PD1) or 4 (RvD1 and RvD5). *p<0.05, **p<0.01, E. coli plus SPM vs. E coli alone. (b) Venn diagrams of genes regulated by resolvins in human MΦ incubated with E. coli. CD40 (TNFRSF5, TNF receptor superfamily member 5), ITGAM (CD11b), PDE (phosphodiesterase), PLA2 (phospholipase A2), PTGS2 (cyclooxygenase-2), PTGER2 (prostaglandin E2 receptor, EP2).