Table 1.
Association of rs62527607[GT] genotype and BAALC expression in the test set and validation set and in the two sets combined
| Test set |
Validation set |
Combined sets |
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| BAALC expression | Low, n = 134 (%) | High, n = 119 (%) | *P value | Low, n = 53 (%) | High, n = 52 (%) | *P value | Low, n = 187 (%) | High, n = 171 (%) | **P value | |
| Genotype counts | GG | 108 (81) | 70 (59) | 43 (81) | 36 (69) | 151 (81) | 106 (62) | |||
| GT | 20 (15) | 46 (39) | 8 (15) | 16 (31) | 28 (15) | 62 (36) | ||||
| TT | 6 (5) | 3 (3) | 2 (4) | 0 (0) | 8 (4) | 3 (2) | ||||
| GT + TT | 26 (19) | 49 (41) | 2.01 × 10−4 | 10 (19) | 16 (31) | 0.16 | 36 (19) | 65 (38) | 9.30 × 10−5 | |
| OR (95% CI) | 2.91 (1.67, 5.16) | 1.91 (0.78, 4.86) | 2.59 (1.62, 4.22) | |||||||
| Allele count | G | 236 (88) | 186 (78) | 94 (89) | 88 (85) | 330 (88) | 274 (74) | |||
| T | 32 (12) | 52 (22) | 3.16 × 10−3 | 12 (11) | 16 (15) | 0.39 | 44 (12) | 68 (18) | 2.83 × 10−3 | |
| OR (95% CI) | 2.06 (1.28, 3.06) | 1.42 (0.64, 3.24) | 1.87 (1.25, 2.85) | |||||||
Test set, Cancer and Leukemia Group B; validation set, German-Austrian AML Study Group. All P values for genotypes compare GG with GT+TT and are obtained from *univariable or **multivariable logistic regression analyses. CI, confidence interval; OR, odds ratio.