Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Mar 2;287(17):13518–13523. doi: 10.1074/jbc.R111.326876

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

PMC Copyright notice

FIGURE 1. — Model of iron delivery in mammalian cells. PCBP1 and PCBP2 bind cytosolic Fe(II) and directly deliver it to ferritin, 2-oxoglutarate dioxygenases (such as PHDs and FIH1), and possibly other non-heme iron enzymes (such as oxo-bridged diiron enzymes). Although mammalian Grx3 has not been characterized, based on the functions of Grx3/4 in yeast, it likely associates with mammalian BolA2, with each glutaredoxin domain coordinating a 2Fe-2S cluster with one BolA2. In a speculative model of iron chaperone function, PCBPs may interact with Grx3-BolA in a way that effects the transfer of iron from one complex to the other. Grx3-BolA may deliver iron to mitochondria (perhaps via mitoNEET (mNT)) for heme and Fe-S cluster biosynthesis. Yfh1 (frataxin), along with Nfs1, Isd11, and Isu (yeast nomenclature), forms the core Fe-S cluster assembly complex in mitochondria. Grx3-BolA may also interact with the cytosolic Fe-S cluster assembly machinery (CIA).