Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Proposed mechanism of Go-GRIN mediated modulation of Sprouty2 inhibitory effects on MAPK activation. A, in the absence of Hu210, Gαo is inactive, and GRIN sequesters Sprouty and prevents it from inhibiting FGF-induced MAPK activation. B, upon stimulation of Go/i-coupled receptors, Gαo is activated and binds to GRIN. Sprouty is released and is able to attenuate FGF activated MAPK. Sprouty2 can potentially inhibit at the level of Grb2 and/or at c-Raf.
