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. 2012 Feb 13;287(18):14912–14922. doi: 10.1074/jbc.M111.322362

FIGURE 5.

FIGURE 5.

Antimetastatic effects of peptides. Lung colonization of B16F10-Nex2 cells in a syngeneic system was used to test the protective activity of C7H2 and N-terminal alanine-substituted analogs Y1A, I2A, S3A, or C4A. Protective activity of peptides injected intraperitoneally with doses of 300 μg using the protocol indicated under “Experimental Procedures” is shown. Mice (n = 5/group) were challenged with 5 × 105 syngeneic B16F10-Nex2 melanoma cells (0.1 ml/mouse). *, p < 0.01; error bars, S.D.