TABLE 1.
Summary of cancer types in human patients where caspase-2 was found down-regulated in comparison with normal tissue
Analysis of differential gene expression is based on publicly available data from the NCBI GEO database (see “Experimental Procedures” for details).
| Type of cancer | p value | Sample size (cancer/normal) | GEO data set identification number | Reference |
|---|---|---|---|---|
| Burkitt's lymphoma | 1.44 × 10−5 | 17/25 | GSE2350 | Basso et al. (34) |
| Centroblastic lymphoma | 2.90 × 10−10 | 28/25 | GSE2350 | Basso et al. (34) |
| Diffuse large B-cell lymphoma | 1.47 × 10−4 | 32/25 | GSE2350 | Basso et al. (34) |
| Chronic lymphocytic leukemia | 7.37 × 10−13 | 34/25 | GSE2350 | Basso et al. (34) |
| Chronic lymphocytic leukemia | 2.10 × 10−5 | 12/31 | GSE60 | Alizadeh et al. (36) |
| Chronic lymphocytic leukemia | 6.23 × 10−38 | 448/74 | GSE13159 | Haferlach et al. (35) |
| Hairy cell leukemia | 3.38 × 10−8 | 16/25 | GSE2350 | Basso et al. (34) |
| Hepatocellular carcinoma | 2.02 × 10−5 | 22/21 | GSE14520 | Roessler et al. (39) |
| Cirrhosis | 1.99 × 10−5 | 58/19 | GSE14323 | Mas et al. (40) |
| Invasive breast carcinoma | 2.99 × 10−7 | 53/6 | GSE9014 | Finak et al. (43) |
| Infiltrating bladder urothelial carcinoma | 2.43 × 10−6 | 13/14 | GSE3167 | Dyrskjot et al. (37) |
| Superficial bladder cancer | 1.47 × 10−6 | 28/14 | GSE3167 | Dyrskjot et al. (37) |
| Ovarian mucinous adenocarcinoma | 9.33 × 10−6 | 13/4 | GSE6008 | Hendrix et al. (38) |
| Ovarian endometrioid adenocarcinoma | 3.03 × 10−5 | 37/4 | GSE6008 | Hendrix et al. (38) |
| Glioblastoma | 2.28 × 10−7 | 22/3 | GSE4536 | Lee et al. (41) |
| Barrett's esophagus | 4.01 × 10−5 | 15/28 | GSE13898 | Kim et al. (42) |
| Esophageal adenocarcinoma | 6.29 × 10−4 | 75/28 | GSE13898 | Kim et al. (42) |