Table 1. Competitive index analysis of S. Typhimurium mutants.
| wt versus | C.I. |
| spe | 0.20±0.18a |
| spe/pLOJ318 | 0.63±0.15b |
| spe/pACYC177 | 0.36±0.11a |
| pot | 0.17±0.15a |
| pot/pLOJ326 | 1.43±0.32b |
The C.I. was calculated as the output ratio of mutant to wt divided by the input ratio. The C.I.s shown for the spe and the spe/pLOJ318 strains are the means of two independent infections of mice, with 4 mice in each infection group. The C.I.s of the other groups are the means of the 4-5 mice infected in each group. Mice were inoculated i.p. with a mixture of two strains comprising ∼5×103 c.f.u. og each strain. Mouse spleens were harvested after 6 days for enumeration of bacterial c.f.u. The different strains used were differentiated on the basis of antibiotic sensitivity. Statistical differences were analyzed by one-way ANOVA using Bonferronís post-test.
a
Significantly different from 1.0
b
Significantly different from corresponding mutant.