Figure 1. Markers of oxidative stress accumulate in and around the dentate gyrus of the hippocampus.

(a) Oxidized 8-deoxyguanosine (8OHDG), a marker of oxidized nucleic acid and (c) hydroxynonenal (HNE), a measure of oxidized lipid, both exhibit localized increases in expression throughout the hippocampus. (b, d) Elevated magnification (boxed areas from a, c) indicated that both these markers express highest levels within the SGZ (arrows). Scale bars: 200 µm (a,c), 100 µm (b,d).