Figure 6. ORGs exhibit elevated levels of expression in multiple models of enhanced neurogenesis, and respond more dramatically to antioxidant administration than normal controls.

Infusion of the antioxidant Edaravone (3 mg/kg/day) produces an larger magnitude of decrease in OR genes in CaMKIIα hyper-neurogenic mice compared to controls for both individual genes (16/20; a) and as a group (b). Running (14d) significantly increases the expression of 11/20 ORG members (c), with a significant group increase (d). (e) RT-PCR measures of OR expression. p*<0.05.