Table 3. In vivo pharmacological profile of compound 22. Inhibition of different behavioral responses after oral administration of the test and reference Compounds.
| Compound | Apomorphine- induced climbing (ED50, mg/kg, po, A) | MK-801-induced hyperactivity (ED50, mg/kg, po, B) | CAT (catalepsy) (ED50 mg/kg,po, C) | C/A | C/B |
| 22 | 3.68 (2.79–4.86)a | 3.58 (2.59–8.28) | >300 | 81.52 | 83.80 |
| risperidone | 0.02 (0.014–0.024) | 0.01 (0.004–1.51) | 0.3 | 15 | 30 |
| clozapine | 7.99 (7.34–8.69) | 5.06 (3.41–9.69) | 92.73 | 11.61 | 18.33 |
| haloperidol | 0.09 (0.054–0.177) | 0.19 (0.15–0.26) | 0.22 | 2.44 | 1.16 |
a
95% Confidence limits given in parentheses.