Table 1. Clinicopthological data and genomic alterations in the 25 Japanese PTC cases.
Case | BRAFV600E | RET/PTC1 rearrangement | CNA | AS-UPD(CN-LOH) | Percent of altered genome | Age | Sex | Tumor size (mm) | Histological type | pEx | pT | pN | M | Vessel invasion | Stage | Recurrence | |
T13 | + | − | − | + | 0.5 | 45 | F | 23 | p | 0 | 1b–m | 1a | 0 | − | III | − | |
T15 | + | − | − | − | 0.0 | 37 | F | 35 | p | 2 | 4a | 1a | 0 | − | I | − | |
T17 | + | − | + | + | 16.8 | 75 | F | 53 | p+poorly | 2 | 4a | 1b | M1–lung | v+++ | IVC | + | |
T21 | + | − | + | − | 1.2 | 63 | F | 23 | p | 1 | 3 | x | 0 | − | III | − | |
T23 | + | − | − | + | 2.3 | 62 | F | 38 | p | 2 | 4a | 1b | 0 | − | IVA | − | |
T24 | + | − | − | − | 0.0 | 60 | F | 22 | p | 1 | 3 | 0 | 0 | − | III | − | |
T25 | + | − | − | − | 0.0 | 36 | F | 27 | p | 1 | 3 | 0 | 0 | − | I | − | |
T30 | + | − | − | − | 0.0 | 74 | F | 39 | p | 1 | 3 | 0 | 0 | − | III | − | |
T45 | + | − | − | − | 0.0 | 69 | F | 36 | p+poorly | 1 | 3 | 1a | 0 | − | III | − | |
T53 | + | − | − | − | 0.0 | 60 | M | 20 | p | 1 | 3 | 1a | 0 | ND | III | − | |
T58 | + | − | − | − | 0.0 | 46 | F | 29 | p | x | x | 1b | 0 | − | IVA | − | |
T08 | − | + | − | − | 0.0 | 22 | F | 15 | p | 1 | 3 | 1b | 0 | v+, ly+ | I | − | |
T18 | − | + | − | − | 0.0 | 18 | F | 33 | p | 1 | 3 | 1b | 0 | − | I | − | |
T19 | − | + | + | − | 1.8 | 36 | F | 20 | p | 0 | 1b | x | 0 | − | I | − | |
T20 | − | + | − | − | 0.0 | 41 | F | 12 | p | 0 | 1b | 1b | 0 | − | I | − | |
T05 | − | − | − | + | 2.0 | 70 | F | 36 | p | 0 | 2 | 1b | 0 | ND | IVA | − | |
T06 | − | − | − | + | 6.0 | 42 | F | 24 | fv | 0 | 2 | 0 | 0 | ND | I | − | |
T07 | − | − | − | + | 2.3 | 46 | F | 8 | p | 1 | 3 | x | 0 | ND | III | − | |
T11 | − | − | − | − | 0.0 | 63 | F | 37 | p | 1 | 3 | 1a | 0 | ND | III | − | |
T27 | − | − | − | − | 0.0 | 49 | F | 24 | p | 0 | 1b | 1b | 0 | ND | IVA | − | |
T32 | − | − | + | − | 1.7 | 56 | M | 45 | fv | 0 | 3 | 1b | 0 | ND | IVA | − | |
T36 | − | − | + | − | 0.3 | 58 | M | 20 | fv | 1 | 3 | 1b | 0 | ND | IVA | − | |
T47 | − | − | − | − | 0.0 | 68 | F | 20 | p | 0 | 1b | 1a | 0 | ND | III | − | |
T48 | − | − | + | − | 1.2 | 81 | F | 25 | p | 1 | 3 | x | 0 | ND | III | − | |
T50 | − | − | + | − | 3.7 | 56 | M | 65 | p+poorly | 1 | 3 | 1a | 0 | − | III | − |
Using the UICC TNM classification.
Other abbreviations, F: female; M: male; p: papillary; fvp: follicular variant; ND: not described.