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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Neurosci Biobehav Rev. 2012 Feb 21;36(5):1357–1375. doi: 10.1016/j.neubiorev.2012.02.011

Table 2.

Motor activity in open-field, Y-maze, or home-cage by transgenic mice expressing human mutated or wild-type (WT) APP genes with or without mutated PS1

Mouse name Activity References
APP695SWE (Tg2576) ↑ or normal Arendash et al., 2004;
Chapman et al., 1999;
Comery et al., 2005;
Deacon et al., 2008;
Dineley et al., 2002;
Gil-Bea et al., 2007;
Gorman and Yellon, 2010;
Holcomb et al., 1998;
1999;
King and Arendash 2002;
Lalonde et al., 2003;
Massaad et al., 2009;
Middei et al., 2004, 2006;
Ognibene et al., 2005
Scholtzova et al., 2009;
Tabuchi et al., 2009
APP695SWE (Tg2123H) normal Hsiao et al., 1995
APP695SWEch normal Savonenko et al., 2003
APP751SWE ↓ and ↑ or normal Dumont et al., 2004;
Heneka et al., 2006;
Huang et al., 2006;
Lalonde et al., 2002b;
Senechal et al., 2008
Van Dam et al., 2003;
Vloeberghs et al., 2004
APP695SWE/Thy1 normal Richardson et al., 2003
APP770SWE ↓ Moechars et al., 1999b
APP751SWE/LD ↑ or ↓ Blanchard et al., 2009
APP/IND ↑ or ↓ Dodart et al., 1999;
Gerlai et al., 2002
Huitron-Resendiz et al., 2002
APP695SWE/IND (TgCRND8 and Tg19959) ↑ or normal Ambrée et al., 2006;
Dumont et al., 2010;
Görtz et al., 2008
Hyde et al., 2005;
Lewejohann et al., 2009;
Touma et al., 2004;
Walker et al., 2011
APP695SWE/IND/tet ↑ Jankowsky et al., 2005b
APP751SWE/IND normal Lee et al., 2004
APP/SWE/IND/J20 normal Galvan et al., 2006
APP/SWE/ARC ↑ Codita et al., 2010
APP695LD ↓ Moechars et al., 1999b
APP/RK ↓ Moechars et al., 1998
APP695WT/Mt2 ↓ Yamaguchi et al., 1991
APP695WT/Thy1 ↓ Moechars et al., 1999b
App695WT APP695mycWT, APP695TRImyc normal Hsiao et al., 1995
APP751WT normal D'Hooge et al., 1996
APP/C104 normal Nalbantoglu et al., 1997
APP/C100-Flag normal Berger-Sweeney et al., 1999
APP/C100/IND ↑ Boon et al., 2010
APP/C100/WT ↑ Boon et al., 2010
APP/C99 ↓ Lalonde et al., 2002a
APP695SWE+PS1/M146L ↑ or normal Arendash et al., 2001;
Holcomb et al., 1998, 1999;
Sadowski et al., 2004
APP695SWE+PS1/M146L/Thy1 ↓ normal Pugh et al., 2007
Pardon et al., 2009
APP695SWEch+PS1/A246E ↓ Liu et al., 2002
APP751SWE/LD+PS1/M146L ↓ Le Cudennec et al., 2008
APP695SWE+PS1/A246E normal Dineley et al., 2002
APP695SWE/co+PS1/ΔE9 ↑ or normal Frye and Walf, 2008;
Hartmann et al., 2010;
Hoojimans et al., 2009;
Lalonde et al., 2004, 2005
Timmer et al., 2010
APP751SWE/LD+PS1/M233+L235P ↑ Faure et al., 2011
APP751SWE+PS2/VG normal Richards et al., 2003
3X-Tg-AD ↓ ↑ or normal Arsenault et al., 2011;
Gimenez-Llort et al., 2007;
Gulinello et al., 2009;
Halagappa et al., 2007;
Nelson et al., 2007;
Ojha et al., 2011;
Pietropaolo et al., 2008;
Pietropaolo et al., 2009
APP knockout ↓ Müller et al., 1994;
Tremml et al., 1998

↑=increase, ↓=decrease, normal=no difference vs controls; WT=wild-type