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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: DNA Repair (Amst). 2012 Mar 13;11(5):480–487. doi: 10.1016/j.dnarep.2012.02.001

Fig. 5.

Fig. 5

Detail views of RNR features and mutated amino acid residues. (A) Close-up of the RNR activity site (ATP cone) with residues indicated that were found to yield a mutator phenotype. (B) Possible effect of the T55I mutation on (d)ATP binding. The isoleucine side chain intrudes in the nucleotide binding area and may interfere with effector binding. (C) Close-up of the R1-R2 interaction area with R1 and R2 mutator residues indicated. The proximity of R1 and R2 mutants coupled with their similar mutational properties and dNTP pool changes support a functional interaction and common mechanism. (D) A close-up view of the RNR specificity site showing important Loop 2 (red) and the G295 and A301 residues, which yield a mutator phenotype upon mutation.