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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: DNA Repair (Amst). 2012 Mar 13;11(5):480–487. doi: 10.1016/j.dnarep.2012.02.001

Fig. 6.

Fig. 6

dNTP pool changes predict mutational specificity. The diagrams show the lacZ sequence at which the G·C→T·A (top) or A·T→T·A (bottom) mutations occur. The red T indicates the misinserted ‘incorrect’ dTTP opposite the relevant template base (underlined), while the blue G or A indicates the ‘correct’ dGTP or dATP competing with the dTTP at the insertion step. The arrows represent the subsequent incorporation of dCTP (next nucleotide) and dATP (next-next nucleotide), which may protect the misinserted base against their exonucleolytic removal. See text for a full description.