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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Dec 3;71(11):978–986. doi: 10.1016/j.biopsych.2011.10.024

Figure 6.

Figure 6

Blocking mGluR5 with MTEP enhances the N-acetylcysteine (NAC)-induced inhibition of cocaine reinstatement. (A) Experimental paradigm for reinstatement testing. SA- self-administration (B) NAC (10 mg/kg, i.p.) reduced active lever presses following cocaine priming, while MTEP (0.1 mg/kg, i.p.) had no effect. However, MTEP enhanced NAC-induced reduction in lever presses (F(4,69)= 9.23, p< 0.001). * p<0.05 compared to extinction, + p<0.05 compared to Sal+Sal, using a Bonferroni post hoc analysis.