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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Am J Obstet Gynecol. 2012 Feb 22;206(5):448.e1–448.e7. doi: 10.1016/j.ajog.2012.02.011

Figure 4.

Figure 4

Copper zinc superoxide dismutase 1 (SOD1) overexpression in vivo abolishes maternal hyperglycemia-induced nitrosative stress and caspase activation. Levels of nitrosylated protein (A), and cleaved caspase-8 and caspase-3 (B) were determined in E8.75 WT embryos from non-diabetic controls (NC), WT embryos and SOD1 overexpressing embryos from diabetic mellitus (DM) WT dams mated with SOD1-Transgenic (Tg) males. Representative images of Western blotting were shown in A (upper panel) and B. The graph in the lower panel of A was data of densitometric analysis. * indicates significant difference (p < 0.05) when compared to other groups. n = 3. In B, experiments were repeated three times with embryos from three different mothers in each group, and identical results were obtained. Cleaved products of caspase-8 and -3 were only present in WT embryos of DM dams.