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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Eur J Med Chem. 2012 Feb 25;51:145–153. doi: 10.1016/j.ejmech.2012.02.035

Scheme 2.

Scheme 2

a) nBuLi, BnBr, THF, 0–30 °C, 18h, 66% b) ethyl 2-cyanoacetate, S8, morpholine, EtOH, Δ, 24 – 48h., 38 % c) p-Nitrophenyl chloroformate, Pyridine, CH2Cl2, r.t. 6 –12h, 77% d) Pyridine, DMAP, THF, r.t. 12–24h, 80–85% e) NaOMe, MeOH, reflux, 3h., 88–90%