Table 1.
MIC and LD50 values for compounds 1–4, 11a, 11b, 16a, and 16b
| MIC (mg/L) |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
S. aureus (VISA Mu50) |
S. aureus (MRSA 494) |
S. aureus (VRSA MI) |
S. pneumoniae (ATCC 49619) |
E. faecium (VRE 7303) |
E. coli (ATCC 25922) |
P. aeruginosa (ATCC 27853) |
K. pneumoniae (CEF 2324) |
E. aerogenes (CEF 3978) |
LD50 (mg/L) |
Therapeutic Indexa |
|
| 1 | 16 | 16 | 8 | 32 | 8 | 32 | 16 | 32 | 32 | 42 | 5 |
| 2 | 2 | 2 | 2 | 8 | 4 | >32 | 32 | 32 | 16 | 52 | 26 |
| 3 | >32 | >32 | >32 | 32 | >32 | >32 | >32 | >32 | 32 | 120 | 4 |
| 4 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 8 | 98 | 3 |
| 11a | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | nd | nd |
| 11bb | nd | nd | nd | nd | nd | nd | nd | nd | nd | nd | nd |
| 16a | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | nd | nd |
| 16b | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | nd | nd |
| Vancomycin | nd | 0.5 | nd | 0.5 | >32 | nd | >32 | nd | nd | nd | nd |
a.
Therapeutic index was calculated as the ratio of LD50/MIC for VRSA.
b.
not determined due to insolubility of compound in media.