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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Expert Opin Biol Ther. 2007 Sep;7(9):1333–1345. doi: 10.1517/14712598.7.9.1333

Figure 1. Long-term expression of GUSB in MPS VII dogs after neonatal retroviral vector-mediated gene therapy.

Figure 1

Newborn MPS VII dogs were injected i.v. with 3 × 109 transducing units/kg of a retroviral vector with the human α1-antitrypsin promoter upstream of the canine GUSB cDNA [29], Serum GUSB activity is shown on a semilog plot versus the age years after retroviral vector transduction. The enzyme activity prior to gene therapy was < 1 U/ml, as indicated by the initial data point. The serum activity in normal dogs Is indicated by the shaded region.

GUSB: Serum β-glucuronidase; MPS: Mucopolysaccharidosis.